P02.97. Lipoic acid supplementation induces a transient stress response and improves episodic memory and cholesterol efflux in humans

Purpose Lipoic acid (LA) shows promise as a beneficial micronutrient in improving health, particularly in the elderly. Clinical and in vitro reports show that LA induces endogenous antioxidants and acts as an anti-inflammatory agent. LA also increases nerve conductance, improves diabetes-induced polyneuropathies, and remediates the age-associated cognitive decline in canines. Furthermore, LA significantly improves hypertriglyceridemia and glucose handling. From our preclinical research we have found that LA primarily influences three areas of health: cognition, stress response, and lipids. This study examines the effects of LA on human subjects in components of each of the three aforementioned areas of health.